Man oh Man oh Man!
I tried so hard to get my vtiger CRM to speed up. It was running slow. Each page took 60 seconds to come up.
Finally dig after dig after dig and this has seemed to work!
comment out just a few lines in include/utils/ListViewUtils.php. (any debug log lines with $list_result)
See this website for details
http://forums.vtiger.com/viewtopic.php?t=13911&postdays=0&postorder=asc&start=20
That made the most significant difference.
Other things helped like reducing the number of “talk backs”. Modify data/CRMEntity.php
http://forums.vtiger.com/viewtopic.php?p=88672#88672